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Phosphorylation of CTP Synthetase on Ser, Ser, Ser, and Ser Regulates the Levels of CTP and Phosphatidylcholine Synthesis in Saccharomyces cerevisiae*

The Saccharomyces cerevisiae URA7-encoded CTP synthetase is phosphorylated and stimulated by protein kinase C. We examined the hypothesis that Ser, Ser, Ser, and Ser, contained in a protein kinase C sequence motif in CTP synthetase, were target sites for the kinase. Synthetic peptides containing a phosphorylation motif at these serine residues served as substrates for protein kinase C in vitro....

Ser - D 1

Estudo piloto sobre alimentos que devem ser evitados nos portadores de psoríase

FUNDAMENT: Psoriasis is a chronic inflammatory systemic disease mediated by immune factors. We will explore the foods that act on these factors contributing to psoriasis. As a systemic disease, which shares the same pathophysiological substrate with other comorbidities, diet also leads to worsening of comorbidities. OBJECTIVE: To indicate a group of foods that can act as a factor of manifestati...

SER-Based Web Graph Decontamination2.4

The creation of a web bubble, or link farm, is a technique used by web spammers to increase the visibility of a target page T. Specialized mobile agents, called Web Marshals, are employed to detect and dismantle link farms. As the number of Web Marshals, as well as the number of hops needed to disassemble a link farm, need to be minimized, this kind of process can be seen as a graph decontamina...

Myofilament Calcium Sensitivity: Mechanistic Insight into TnI Ser-23/24 and Ser-150 Phosphorylation Integration

Troponin I (TnI) is a major regulator of cardiac muscle contraction and relaxation. During physiological and pathological stress, TnI is differentially phosphorylated at multiple residues through different signaling pathways to match cardiac function to demand. The combination of these TnI phosphorylations can exhibit an expected or unexpected functional integration, whereby the function of two...